I wrote a GPU-less billion-vector DB for molecule search (live demo)

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Input a SMILES string (or pick one molecule from the examples) and it returns up to 100k molecules closest in 3-D shape or electrostatic similarity – from 10+ billion scale databases — typically in under 5-10 s. *Why it might interest HN* * Entire index lives on disk — no GPU at query-time, less than ~10 GB RAM total. * Built from scratch (no FAISS index / Milvus / Pinecone). * Index-build cost: one Nvidia T4 (~ 300USD) for one 5.5B database. * Open to anyone, predict ADMET, export results as CSV/SDF. Full write-up & benchmarks (DUD-E, LIT-PCBA, SVS) in the pre-print: https://chemrxiv.org/engage/chemrxiv/article-details/6725091...

Visit product View on Hacker NewsJun 26, 2025

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Indie HackersFits the IH revenue-focused audience · Missing: supports, reddit linkedin, podcasting

73%73% predicted probability of success on Indie Hackers, based on ML models trained on real launch data.

Hacker NewsStrong engagement from HN community · Strong signals: io · Missing: https docs, excited, just released

72%72% predicted probability of success on Hacker News, based on ML models trained on real launch data.

nativeThis product was originally launched on this platform.

Product HuntOn track for Day 1 leaderboard · Strong signals: open · Missing: mac, agents, macos

61%61% predicted probability of success on Product Hunt, based on ML models trained on real launch data.

TrustMRRLess likely to generate early MRR · Missing: mobile apps, ios, personal

35%35% predicted probability of success on TrustMRR, based on ML models trained on real launch data.

AppSumoMay struggle as an AppSumo deal · Missing: plus, platform, intuitive

26%26% predicted probability of success on AppSumo, based on ML models trained on real launch data.

Acquire.comPre-revenue stage for this audience · Missing: arr, mrr, revenue

16%16% predicted probability of success on Acquire.com, based on ML models trained on real launch data.

BetaListMay not resonate with beta-testers · Missing: web3, chat, crypto

6%6% predicted probability of success on BetaList, based on ML models trained on real launch data.

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